Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties
نویسندگان
چکیده
Abstract In this work, we investigated the effects of vacuum pumping on both loading efficiencies and release kinetics halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid sodium diclofenac were selected. For comparison, was conducted platy kaolinite to explore key role hollow tubular morphology filling mechanism halloysite. The pressure conditions used protocol interpreted discussed basis thermodynamic results provided by Knudsen thermogravimetry, which demonstrated ethanol confinement inside cavity. Several techniques (TEM, FTIR spectroscopy, DLS $$\zeta$$ ζ -potential experiments) employed characterize nanoclays. Besides, drugs studied according mechanism. This work represents a further step for development nanotubular carriers tunable feature based localization into carrier. Graphic abstract efficiency is enhanced reduction protocol.
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ژورنال
عنوان ژورنال: Journal of nanostructure in chemistry
سال: 2021
ISSN: ['2008-9244', '2193-8865']
DOI: https://doi.org/10.1007/s40097-021-00391-z